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c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.
Gravina GL, Festuccia C, Popov VM, Di Rocco A, Colapietro A, Sanità P, Monache SD, Musio D, De Felice F, Di Cesare E, Tombolini V, Marampon F. Gravina GL, et al. Radiat Res. 2016 Apr;185(4):411-22. doi: 10.1667/RR14237.1. Radiat Res. 2016. PMID: 27104757
We have previously reported that the MEK/ERK pathway sustains in vitro and in vivo transformed phenotype and radioresistance of embryonal rhabdomyosarcoma (ERMS) cell lines. Furthermore, we found that aberrant MEK/ERK signaling activation promotes c-Myc oncoprotein …
We have previously reported that the MEK/ERK pathway sustains in vitro and in vivo transformed phenotype and radioresistance of embryonal …
Evaluation of Endoglin (CD105) expression in pediatric rhabdomyosarcoma.
Di Paolo V, Russo I, Boldrini R, Ravà L, Pezzullo M, Benedetti MC, Galardi A, Colletti M, Rota R, Orlando D, Crocoli A, Peinado H, Milano GM, Di Giannatale A. Di Paolo V, et al. BMC Cancer. 2018 Jan 5;18(1):31. doi: 10.1186/s12885-017-3947-4. BMC Cancer. 2018. PMID: 29304781 Free PMC article.
Endoglin (CD105) is a protein predominantly expressed in proliferating endothelium and the IMVD determined by this marker measures specifically the neovascularization. In this study, we investigated the CD105 expression in pediatric rhabdomyosarcoma and assessed the …
Endoglin (CD105) is a protein predominantly expressed in proliferating endothelium and the IMVD determined by this marker measures specifica …
In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.
Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM. Ignatius MS, et al. Cancer Cell. 2012 May 15;21(5):680-693. doi: 10.1016/j.ccr.2012.03.043. Cancer Cell. 2012. PMID: 22624717 Free PMC article.
Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. ...
Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. ...
Laser speckle contrast analysis (LASCA) technology for the semiquantitative measurement of angiogenesis in in-ovo-tumor-model.
Pion E, Asam C, Feder AL, Felthaus O, Heidekrueger PI, Prantl L, Haerteis S, Aung T. Pion E, et al. Microvasc Res. 2021 Jan;133:104072. doi: 10.1016/j.mvr.2020.104072. Epub 2020 Sep 17. Microvasc Res. 2021. PMID: 32949573
Aim of the present study was to utilize the chick chorioallantoic membrane (CAM) model as an in-ovo-tumor-model which enables rapid neovascularization of tumors while allowing real-time observation of the microcirculation via LASCA. METHODS: Fertilized chicken eggs were gr …
Aim of the present study was to utilize the chick chorioallantoic membrane (CAM) model as an in-ovo-tumor-model which enables rapid neova …
Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma.
Bersani F, Taulli R, Accornero P, Morotti A, Miretti S, Crepaldi T, Ponzetto C. Bersani F, et al. Eur J Cancer. 2008 Apr;44(6):876-84. doi: 10.1016/j.ejca.2008.02.022. Epub 2008 Mar 14. Eur J Cancer. 2008. PMID: 18342500
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood, divided into two major histological subtypes, embryonal (ERMS) and alveolar (ARMS). To explore the possibility that the proteasome could be a target of therapeutic value in rhabdomyosarco …
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood, divided into two major histological subtypes, embryona …
Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors.
Schweigerer L, Neufeld G, Mergia A, Abraham JA, Fiddes JC, Gospodarowicz D. Schweigerer L, et al. Proc Natl Acad Sci U S A. 1987 Feb;84(3):842-6. doi: 10.1073/pnas.84.3.842. Proc Natl Acad Sci U S A. 1987. PMID: 2433691 Free PMC article.
Cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor (bFGF) gene and they produce bFGF, which is apparently composed of two microheterogenous forms with Mrs of 16,500 and 17,200, respectively. bFGF derived from the rhabdomyos …
Cultured human embryonal rhabdomyosarcoma cells express the basic fibroblast growth factor (bFGF) gene and they produce bFGF, …
Multiple angiogenesis stimulators in a single malignancy: implications for anti-angiogenic tumour therapy.
Pavlakovic H, Havers W, Schweigerer L. Pavlakovic H, et al. Angiogenesis. 2001;4(4):259-62. doi: 10.1023/a:1016045012466. Angiogenesis. 2001. PMID: 12197470
Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, produces in vivo at least three biologically active angiogenesis stimulators (vascular endothelial growth factor, basic fibroblast growth factor and interleukin-8). ...
Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, produces in vivo at least three biolog …
FOXM1 expression in rhabdomyosarcoma: a novel prognostic factor and therapeutic target.
Kuda M, Kohashi K, Yamada Y, Maekawa A, Kinoshita Y, Nakatsura T, Iwamoto Y, Taguchi T, Oda Y. Kuda M, et al. Tumour Biol. 2016 Apr;37(4):5213-23. doi: 10.1007/s13277-015-4351-9. Epub 2015 Nov 9. Tumour Biol. 2016. PMID: 26553361
The transcription factor Forkhead box M1 (FOXM1) is known to play critical roles in the development and progression of various types of cancer, but the clinical significance of FOXM1 expression in rhabdomyosarcoma (RMS) is unknown. This study aimed to determine the role of …
The transcription factor Forkhead box M1 (FOXM1) is known to play critical roles in the development and progression of various types of canc …
Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression.
Skrzypek K, Kusienicka A, Szewczyk B, Adamus T, Lukasiewicz E, Miekus K, Majka M. Skrzypek K, et al. Oncotarget. 2015 Oct 13;6(31):31378-98. doi: 10.18632/oncotarget.5145. Oncotarget. 2015. PMID: 26384300 Free PMC article.
Rhabdomyosarcoma (RMS) is a soft tissue sarcoma, which may originate from impaired differentiation of mesenchymal stem cells (MSC). ...To conclude, our results suggest that activation of MET signaling may cause defects in myogenic differentiation leading to rhabdomyosar …
Rhabdomyosarcoma (RMS) is a soft tissue sarcoma, which may originate from impaired differentiation of mesenchymal stem cells (MSC). . …